都市激情在线亚洲国产91_欧美日韩国产国语对白_av成人毛片在线免费观看_少妇爆乳无码专区网站_亚洲Aⅴ无码吞精久久AV_亚洲AV毛片一区无码日韩_国产成人精品1024视频网站_最新综艺节目国产精品喷浆_国产在线拍揄自揄视频网站_天天少妇被猛烈进入在线播放

3358288340
CN
CN EN
Kexing Biopharm's clinical trial application approved for small-molecule oral drug SHEN26 Capsule against COVID-19

Release date:2022 - 07 - 17

IND application approved for SHEN26 Capsule

On the evening of July 17, 2022, Kexing Biopharm Co., Ltd. (hereinafter referred to as "the Company" or "Kexing Biopharm") announced that it had received the Notice of Approval for Drug Clinical Trial issued by the National Medical Products Administration, indicating that the clinical trial of small-molecule oral drug SHEN26 Capsule against COVID-19 jointly developed by Shenzhen Kexing and Shenzhen Antiv was approved.
Main Contents of Notice of Approval for Drug Clinical Trial

Drug Name: SHEN26 Capsule

Acceptance No.: CXHL2200414, CXHL2200415

Review conclusion: According to the Drug Administration Law of the People's Republic of China and relevant regulations, SHEN26 Capsule meets the relevant requirements for drug registration, so it is agreed to carry out the clinical trial for the treatment of patients with COVID-19 as per the submitted protocol.


About SHEN26

SHEN26 is a broad-spectrum and potent inhibitor against RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. It exerts  antiviral effect by inhibiting the synthesis of viral nucleic acid, showing in vitro inhibitory activity against multiple SARS-CoV-2 variants (wild-type, Alpha, Beta, Delta, and Omicron).

The in-vitro antiviral test data showed that the EC50 of SHEN26 against Omicron variant was 13 nM, with 103X inhibitory activity compared to Remdesivir; in -vivo PD   studies showed that SHEN26 at 50 mg/kg was equivalent to Molnupiravir at 200 mg/kg against SARS-CoV-2, and SHEN26 significantly reduced the viral titer in lung tissues and improved the lesions in the K18-hACE2 mouse model infected with SARS-CoV-2, indicating significant improvement of tissues damaged by SARS-CoV-2.

The safety analysis demonstrated that SHEN26 had a low risk of off-target side effects, with negative results in teratogenicity and mutagenicity, showing a high therapeutic index and good safety.

This project is among the key projects for risk prevention and control and emergency technology and equipment for public safety supported by the Ministry of Science and Technology of the People's Republic of China, one of the 2021 Special Emergency Projects on Prevention and Control of SARS-CoV-2 Infection granted by Guangdong Province, and also amid   "Three Majors" (major projects, major enterprises and major regions in the biomedical industry) Innovation Projects designated by Guangdong Medical Products Administration.


国产欧美日韩一区二区搜索 | 日韩特级毛片免费观看视频 | 成年视频xxxxx在线 | 免费一级毛片在线观看 | 好爽插到我子宫了高清在线 | 99RE久久精品国产 | 日欧137片内射在线视频播放 | 日韩电影一二三区 | 日本一区二区三区在线视频观看免费 | 亚洲中文字幕无码中文字无摸 | 男人猛躁进女人免费播放 | 亚洲色欲色郤久久综合影院 | 欧美成人精品午夜免费影视 | 欧美日韩一区二区精品视频在线观看 | 美女隐私黄www视频 日本电影亚洲欧美精品素人 | 国产成人精品亚洲一区 | 熟女作爱一区二区视频 | 东京热男人aV天堂 | 久本草在线中文字幕亚洲 | 亚洲AV无码一区二区三区在线高 | 国产成人欧美日韩在线电影 | 国产在线拍揄自揄拍无码APP | 狠狠色婷婷久久一区二区三区91 | 久久久久久亚洲AV无码专区 | 午夜.DJ高清在线观看免费7 | 亚洲精品嫩草研究院久久 | 波多野结衣高清无碼中文字幕 | 午夜精品久久久久久不卡AV | 国产福利在线免费 | 欧美自拍另类综合专区 | 午夜亚洲国产理论片一二三四 | 亚洲蜜桃AV永久无码精品放毛片 | AV无码人妻一区二区三区在线 | 91色老久久精品偷偷蜜臀 | 少妇高潮一区二区三区99 | 影音先锋AV成人资源站在线播放 | 又黄又刺激的网站 | 50岁老熟女露脸25分钟91 | 国产精品jizz在线观看老狼 | 为您提供久久久久国产精品 | 国产精品亚洲综合日韩在线 |